Assistant Professor

1. 2013-09 to 2020-08: Ph.D. in Mechanical Engineering, Tsinghua University (Supervisor: Prof. Wei Sun)

2. 2016-12 to 2017-05: Visiting Scholar, University of Erlangen-Nuremberg, Germany

3. 2009-09 to 2013-07: B.Eng. in Mechanical Engineering, Tsinghua University

1. 2025-01 to Present: Assistant Professor, Department of Mechanical Engineering, Tsinghua University

2. 2023-02 to 2024-12: Assistant Researcher, Department of Mechanical Engineering, Tsinghua University

3. 2021-01 to 2023-01: Postdoctoral Fellow, Department of Mechanical Engineering, Tsinghua University

Biomaterials Engineering and Devices

Exploration of Biomedical Mechanical Engineering

Biomanufacturing and Medical Equipment

Research Interests: Cardiac Regeneration, Biomanufacturing, Artificial Intelligence

Facing the major scientific and technological needs and clinical challenges in cardiac regeneration, the researcher proposed a development-inspired and manufacturing-guided regenerative engineering strategy, and established a myocardial tissue biomanufacturing technology system covering structural biomimetics, vascular coupling, and functional regulation, providing innovative approaches for the regenerative repair of diseases such as myocardial infarction. The main achievements are as follows:

1) To address the challenge of replicating complex structures, a microfluidic spinning rotational printing technology was developed. Through biomimetic core-sheath fibers and dynamic curved surface printing, precise construction from cell alignment to the cardiac spiral chamber was achieved.

2) To address the challenge of insufficient vascular perfusion in tissues, a step-by-step nested embedded printing technology for myocardium-vessels was established. By integrating sacrificial template printing and organoid self-organization, the coupled construction from perfusion main channels to capillary microvessels was realized.

3) To address the challenge of immature tissue function, a multi-modal dynamic training and machine learning evaluation system was established, which effectively improved the maturity of in vitro myocardium. Myocardial repair effects were verified in animal models of myocardial infarction.

4) Further expanding to the frontiers of space life science, an automated bioprinter was developed and launched on a commercial satellite, achieving in-orbit 3D printing of complex living tissues. A new rule that microgravity enhances cellular drug sensitivity was also discovered.

In recent years, the researcher has presided over multiple projects including the National Natural Science Foundation of China (Young Scientists Fund), a sub-project of the National Key R&D Program, and the General Program of the Beijing Municipal Natural Science Foundation. As a corresponding author, numerous papers have been published in journals such as Cell Biomaterials, Matter, Trends in Biotechnology, and Advanced Materials. The research achievements have been reported by media including Guangming Network and MIT Technology Review.

He has received honors including the Excellent Oral Presentation Award at the China Biomaterials Conference, the Second Prize of the Invention Award of the China Machinery Industry Science and Technology Award, being selected into the Young Talent Support Program of the Beijing Association for Science and Technology, and the Young Scientist Award of the International Society for Biomanufacturing (the only recipient from Asia).

1. Beijing Natural Science Foundation General Project (Project No. 7252285): Research on 3D Printing Construction of Complex Cardiac Tissues Based on Porous Support Bath, 2025/01-2027/12, 200,000 RMB, In Progress, Project Leader

2. National Key R&D Program (Project No. 2023YFB4605802): Development of Additive Manufacturing Technology and Equipment for Bionic Heterogeneous Tissue Engineering Meniscus, 2024/01-2026/12, 630,000 RMB, In Progress, Sub-project Leader

3. National Natural Science Foundation of China Youth Science Fund (Project No. 52305314): Research on Bioprinting Construction of Ventricular Models Mimicking Cardiac Helical Structure, 2024/01-2026/12, 300,000 RMB, In Progress, Project Leader

4. Key Laboratory of Advanced Equipment Interface Science and Technology Independent Research Project (Project No. SKLT2024Z17): Integrated Printing-Cultivation Construction of Complex Cardiac Soft Tissues, 2024/06-2025/12, 300,000 RMB, In Progress, Project Leader

5. Plastic Surgery Hospital, Chinese Academy of Medical Sciences: Development of Bioprinting Scaffolds for Craniofacial Bone Defect Repair, 2023/06-2025/12, 99,400 RMB, In Progress, Project Leader

6. Key Laboratory of Pediatric Major Diseases, Ministry of Education Open Research Project: Relationship Between Immune Cell Distribution, Functional Inhibition, and Spatial Heterogeneity of Tumor Cells, 2024/01-2024/12, 70,000 RMB, Completed, Project Leader

7. China Aerospace Science and Technology Innovation Institute Cross-Center Phase II Guidance Fund: Bioprinting Technology for Complex Tissues and Organs in Space Environment, 2023/12-2024/10, 200,000 RMB, Completed, Project Leader

8. China Postdoctoral Science Foundation Pre-Station Special Funding (Project No. 2021TQ0184), 2021/06-2023/01, 180,000 RMB, Completed, Project Leader

9. China Postdoctoral Science Foundation General Funding (Project No. 275787), 2021/11-2023/01, 80,000 RMB, Completed, Project Leader

In recent years, the researcher has published 24 papers in authoritative journals as first author or corresponding author, including Cell Press series journals (Cell Biomaterials, Matter, Trends in Biotechnology), Advanced Materials (2 papers), Materials Today, Advanced Functional Materials, Advanced Science, and Biomaterials. Among them, 3 papers are ESI highly cited/hot papers, 2 papers are featured on the journal cover/back cover, and 17 papers are in JCR Q1 zone. In total, 43 papers have been published (cited over 1,800 times, H-index 22), 15 invention patents have been authorized or filed, and 1 monograph entitled Three-Dimensional Printing Technology and Application of Biomaterials has been co-authored.

Selected Publications

1. Fang Yongcong*, Lu Bingchuan, Sun Ruobin, Yang Pengcheng, Ye Yuxuan, Ye Min, Zhang Zhenrui, Yang Yi, Liu Zibo, Xia Jingjing, Zhang Ting*, Xiong Zhuo*. Scalable fabrication of aligned myocardial tissues with native-like helical architecture for heart repair. Cell Biomaterials, 2026: 100306

2. Fang Yongcong, Yang Huayong*. Can AI transform biofabrication for clinical translation? Bio-Design and Manufacturing, 2026, 9(1): 1-3

3. Zhou Xianhao, Zhang Zhenrui, Yu Jintian, Ma Lixi, Ma Sicheng, Wu Bingyan, Wang Zixuan, Zhang Ting, Fang Yongcong*, Xiong Zhuo*, AI-driven interpretation and prediction of embedded printability based on rheology. Bio-Design and Manufacturing, 2026, 9(1): 63-79

4. Fang Yongcong*, Hao Wenshuai, Xiong Zhuo*. On-orbit 3D bioprinting for tumor modeling in space. Trends in Biotechnology, 2025, 43(11): 2690-2693.

5. Duan Jing, Fang Yongcong*, Tian Yueming, Wang Ziyu, Yang Bin*, Xiong Zhuo*. 3D bioprinting of prevascularized bone organoids for rapid in situ cranial bone reconstruction. Advanced Healthcare Materials, 2025, 14(16): 2501376.

6. Deng Heyuan, Fang Yongcong*, Gao Zhengxun, Wu Bingyan, Zhang Ting*, Xiong Zhuo*. Mechanical regulation and 3D bioprinting of native tissue-inspired granular composite hydrogels. Bio-Design and Manufacturing, 2025, 8(4): 570-580.

7. Fang Yongcong*, Wu Bingyan, Wang Zixuan, Xiong Zhuo*. Biofabrication beyond Earth: Intelligent bioprinting for space medicine. Matter, 2025, 8(10): 102460.

8. Tian Yueming, Zhang Zhenrui, Wu Bingyan, Liu Zibo, Zhang Ting, Fang Yongcong*, Xiong Zhuo*. Integrating periosteum derived organoids and 3D printed scaffolds for enhanced craniofacial bone regeneration. Materials Today Communications, 2025, 49: 113931.

9. Zhang Zhenrui^#, Zhou Xianhao^#, Fang Yongcong*, Xiong Zhuo*, Zhang Ting*. Artificial intelligence-driven 3D bioprinting for regenerative medicine: from bench to bedside. Bioactive Materials, 2025, 45: 201-230. （ESI hot paper）

10. Mo Xingwu^#, Zhang Yanmei^#, Wang Zixuan^#, Zhou Xianhao, Zhang Zhenrui, Fang Yongcong*, Fan Zilian, Guo Yihan, Zhang Ting*, Xiong Zhuo*. Satellite-based on-orbit printing of 3D tumor models, Advanced Materials, 2024, 36(34): e2309618.

11. Wu Bingyan^#, Zeng Zhaoxi, Fang Yongcong*, Zhang Zhenrui, Tian Yueming, Lu Bingchuan, Li Binhan, Liu Zibo, Zhang Ting, Xiong Zhuo*. Omnidirectional elastic constraint-based embedded 3D printing in non-yield stress fluids for engineering complex tissues. Materials Today, 2024, 80: 74-86.

12. Zhou Xianhao^#, Fang Yongcong*, Zhang Ting, Xiong Zhuo*. Retrospective: advances and opportunities of 3D bioprinting in China over three decades. Additive Manufacturing Frontiers, 2024, 3(4): 200157.

13. Fang Yongcong^#,*, Xiong Zhuo*. Towards personalized medicine: unlocking on-demand organ manufacturing through 3D bioprinting. The Innovation Life, 2024, 2:100096.

14. Fang Yongcong^#, Guo Yihan, Wu Bingyan, et al. Expanding embedded 3D bioprinting capability for engineering complex organs with freeform vascular networks. Advanced Materials, 2023, 35(22), 2205082. （ESI highly cited paper）

15. Fang Yongcong^#, Wang Chengjin^#, Liu Zibo, et al. 3D printed conductive multiscale nerve guidance conduit with hierarchical fibers for peripheral nerve regeneration. Advanced Science, 2023, 10(12): 2205744. （ESI highly cited paper）

16. Fang Yongcong, Ji Mengke, Yang Yi, et al. 3D printing of vascularized hepatic tissues with a high cell density and heterogeneous microenvironment. Biofabrication, 2023, 15(4):45004. (IF: 9.0)

17. Fang Yongcong, Ji Mengke, Wu Bingyan, et al. Engineering highly vascularized bone tissues by 3D printing of prevascularized spheroids. ACS Applied Materials & Interfaces, 2023, 15(37):43492-43502. (IF: 9.5)

18. Fang Yongcong^#, Guo Yihan, Ji Mengke, et al. 3D printing of cell-laden microgel-based biphasic bioink with heterogeneous microenvironment for biomedical applications, Advanced Functional Materials, 2022, 32(13): 2109810.

19. Fang Yongcong^#, Sun Wei, Zhang Ting, et al. Recent advances on bioengineering approaches for fabrication of functional engineered cardiac pumps: A review, Biomaterials, 2022, 280: 121298.

Patents/Technology Disclosures

1. Xiong Zhuo, Tian Yueming, Fang Yongcong, Zhang Ting, Zhang Zhenrui, Liu Zibo. A Method and Application for Room Temperature Collaborative 3D Printing of Polymer Frameworks and Cell-Laden Gels, 2025/01/08, China

2. Zhang Ting, Fang Yongcong, Zhang Zhenrui, Xiong Zhuo, Zhou Jinpeng, Hong Shaotong, Zhou Xianhao. A Bioprinter Nozzle Structure and Printing Method with Decoupled Silk Height and Width Control, 2024/11/27, China, CN202411862997.1

3. Xiong Zhuo, Wu Bingyan, Fang Yongcong, Zhang Ting. A Suspension Printing Method and Application Based on Non-Yield Stress Fluids, 2024/05/08, China, CN202410792240.3

4. Xiong Zhuo, Fang Yongcong, Zhang Zhenrui, Mo Xingwu, Zhang Ting, Wang Zixuan. Bioink, Suspension Medium, and Suspension 3D Printing Method for Space Tissue and Organ Model Construction, 2023/11/30, China, CN202311572657.0

5. Fang Yongcong, Xiong Zhuo, Sun Ruobin, Ouyang Liliang, Zhang Ting. A Method for Suspension Printing and In Situ Cultivation of Tissues or Organs Based on Porous Support Bath, 2023/12/08, China, CN202311658365.9

6. Fang Yongcong, Xiong Zhuo, Wang Ge, Ouyang Liliang, Zhang Juan, Zhang Ting. A Method for Constructing Flexible Electronic Devices Based on Suspension 3D Printing, 2023/11/30, China, CN202311632372.1

7. Fang Yongcong, Xiong Zhuo, Zhang Ting. A 3D Printing Bioink Based on Gel Microspheres and Its Application, 2021/05/14, China, CN202110526911.8

8. Chen Mingxue, Li Yangyang, Fang Yongcong, Zhou Yixin, Yang Dejin, Shao Hongyi, Zhang Songyang. A Silk Fibroin Bioink and Its Preparation Method and Application, 2022/08/10, China, ZL202210959142.5

9. Xiong Zhuo, Fang Yongcong, Zhang Ting, Guo Yihan, Guo Yujiang. A Multi-Level Suspension Printing Method for Constructing Complex Heterogeneous Tissues/Organs, 2022/10/21, China, ZL202110526251.3 (International PCT Patent)

10. Xiong Zhuo, Fang Yongcong, Zhang Ting, Lu Bingchuan. An Artificial Ventricle with Biomimetic Helical Oriented Microstructures and Its Preparation Method, 2022/05/03, China, ZL202110598810.1

11. Xiong Zhuo, Fang Yongcong, Zhang Ting. A Method for Constructing Fiber Bundle/Tissue Structures with Heterogeneous Functional Fibers and Vascular Channels, 2022/08/12, China, ZL202110598763.0

12. Zhang Ting, Fang Yongcong, Sun Wei, Jia Bo. A Biomimetic Vascularized Soft Tissue with Multi-Layer Vascular Structures and Its Preparation Method, 2017/09/29, China, ZL201710904777.4

13. Sun Wei, Fang Yongcong, Zhang Ting, Liverani Liliana, Bocaccini Aldo. A Biomimetic Tissue Engineering Scaffold with Microporous and Nanofiber Composite Structures and Its Preparation Method, 2017/09/30, China, ZL201710939000.1

14. Zhang Ting, Fang Yongcong, Sun Wei, Lin Feng, Zhang Lei, Zhao Yaling. A Biomimetic Tissue Engineering Scaffold with Internal Channel Networks and Oriented Pore Structures and Its Preparation Method and Application, 2019/01/04, China, ZL201510784043.8

He has served as a member of the Biomanufacturing Branch of the Chinese Mechanical Engineering Society, a director of the Beijing Society for Biomedical Engineering, a member of the Structural Heart Disease Professional Committee of the Chinese Research Hospital Association, and a young member of the Additive Manufacturing Branch of the Chinese Mechanical Engineering Society, among other positions. He also acts as a young editorial board member or guest editor for international journals including The Innovation (a collaborative journal with Cell Press), Exploration, Biodesign & Manufacturing, Additive Manufacturing Frontiers, and BMEMat. He has guest-edited a special issue on AI-enabled biomanufacturing for Biodesign & Manufacturing and was selected as an Outstanding Young Editorial Board Member by journals such as Additive Manufacturing Frontiers. In addition, he has chaired symposia or delivered invited talks more than ten times at important conferences including the International Conference on Biomanufacturing and the TERMIS-AP Annual Meeting.